Original Data

Severe Diabetic Nephropathy in Type 1 Diabetes and Pregnancy - A Case Series

Giorgina B. Piccoli¹, Elisabetta Tavassoli², Carmela Melluzza², Giorgio Grassi³, Clara Monzeglio², Valentina Donvito², Filomena Leone², Rossella Attini², Sara Ghiotto¹, Roberta Clari¹, Irene Moro¹, Federica Fassio², Silvia Parisi², Eleonora Pilloni², Federica N. Vigotti¹, Domenica Giuffrida⁴, Alessandro Rolfo⁴, Tullia Todros^2,4

Manuscript submitted March 7, 2013; resubmitted April 16, 2013; accepted April 25, 2013.

Keywords: type 1 diabetes, diabetic nephropathy, pregnancy, pre-term delivery, nephritic syndrome

Abstract

BACKGROUND: Diabetes and nephropathy are important challenges during pregnancy, increasingly encountered because of the advances in maternal-fetal care. AIM: To evaluate the maternal and fetal outcomes recorded in "severe" diabetic nephropathy in type 1 diabetic patients referred to nephrological healtcare. METHODS: The study was performed in an outpatient unit dedicated to kidney diseases in pregnancy (with joint nephrological and obstetric follow-up and strict cooperation with the diabetes unit). 383 pregnancies were referred to the outpatient unit in 2000-2012, 14 of which were complicated by type 1 diabetes. The report includes 12 deliveries, including 2 pregnancies in 1 patient; one twin pregnancy; 2 spontaneous abortions were not included. All cases had long-standing type 1 diabetes (median of 21 (15-31) years), relatively high median age (35 (29-40) years) and end-organ damage (all patients presented laser-treated retinopathy and half of them clinical neuropathy). Median glomerular filtration rate (GFR) at referral was 67 ml/min (48-122.6), proteinuria was 1.6 g/day (0.1-6.3 g/day). RESULTS: Proteinuria steeply increased in 11/12 patients, reaching the nephrotic range in nine (6 above 5 g/day). One patient increased by 2 chronic kidney disease (CKD) stages. Support therapy included blood pressure and diabetes control, bed rest, and moderate protein restriction. All children were preterm (7 early preterm); early spontaneous labor occurred in 4/12 patients. All singletons were appropriate for gestational age and developed normally after birth. The male twin child died 6 days after birth (after surgery for great vessel transposition). CONCLUSIONS: Diabetic patients with severe diabetic nephropathy are still present a considerable challenge. Therefore, further investigations are required, particularly on proteinuria management and the occurrence of spontaneous labor.

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