Original Data

German New Onset Diabetes in the Young Incident Cohort Study: DiMelli Study Design and First-Year Results

Leonore Thümer¹, Kerstin Adler¹, Ezio Bonifacio², Frank Hofmann³, Manfred Keller³, Christine Milz³, Axel Munte^3,4, Anette-Gabriele Ziegler^1,4

Manuscript submitted October 16, 2010; resubmitted October 31, 2010; accepted November 1, 2010.

Keywords: type 1 diabetes, type 2 diabetes, diabetes registry, epidemiology, classification, identification, youth

Abstract

BACKGROUND: Diabetes incidence in childhood and youth is increasing worldwide, including autoimmune and non-autoimmune cases. Recent findings suggest that there is a larger than expected proportion of type 2 diabetes in youth, and potential cases of intermediate diabetes phenotypes. Most pediatric diabetes registries focus on type 1 diabetes. Also, there is an absence of reliable data on type 2 diabetes incidence in youth. AIMS: The DiMelli study aims to establish a diabetes incidence cohort registry of patients in Germany, diagnosed with diabetes mellitus before age 20 years. It will be used to characterize diabetes phenotypes by immunologic, metabolic, and genetic markers. DiMelli will assess the contribution of obesity and socio-demographic factors to the development of diabetes in childhood and youth. METHODS: Recruitment of patients started in 2009, and is expected to continue at a rate of 250 patients per year. RESULTS: 84% of the 216 patients recruited within the first year were positive for multiple islet autoantibodies, 12% for one islet autoantibody, and 4% were islet autoantibody-negative. Patients with multiple islet autoantibodies were younger and had lower fasting C-peptide levels, compared to islet autoantibody-negative patients (median age 10.0 vs. 14.1 years, p < 0.01). CONCLUSIONS: Results from the first year of the study show that DiMelli will help to reveal new knowledge on the etiology of diabetes, and the contribution of genetic predisposition and environmental risk factors to the different types of diabetes.

Fulltext: HTML , PDF (107KB)

This article has been cited by other articles:

	Ambient air pollution and early manifestation of type 1 diabetes Beyerlein A, Krasmann M, Thiering E, Kusian D, Markevych I, D'Orlando O, Warncke K, Jochner S, Heinrich J, Ziegler AG Epidemiology 2015. 26(3):E31-E32
	Achievement of metabolic control goals set by the American Diabetes Association and the International Society for Pediatric and Adolescent Diabetes in pediatric patients with type 1 diabetes from Spain Enes P, Martin-Frias M, Alvarez MA, Yelmo R, Alonso M, Barrio R Diabetes Res Clin Pract 2015. 107(2):300-305
	Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes Winkler C, Krumsiek J, Buettner F, Angermüller C, Giannopoulou EZ, Theis FJ, Ziegler AG, Bonifacio E Diabetologia 2014. 57(12):2521-2529
	Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression Raab J, Giannopoulou EZ, Schneider S, Warncke K, Krasmann M, Winkler C, Ziegler AG Diabetologia 2014. 57(5):902-908
	Does diabetes appear in distinct phenotypes in young people? Results of the diabetes mellitus incidence Cohort Registry (DiMelli) Warncke K, Krasmann M, Puff R, Dunstheimer D, Ziegler AG, Beyerlein A Plos One 2013. 8(9):e74339
	Concentration and activity of the soluble form of the interleukin-7 receptor α in type 1 diabetes identifies an interplay between hyperglycemia and immune function Monti P, Brigatti C, Krasmann M, Ziegler AG, Bonifacio E Diabetes 2013. 62(7):2500-2508