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The Review of Diabetic Studies
Vol.9,
Issue
4-Winter
2012
Quarterly
ISSN print edition 1613-6071
ISSN online edition 1614-0575
Content
of No. 4 -
2012
Chapter I. Pathogenesis
Genetic Analysis of Type 1 Diabetes: Embryonic Stem Cells as New Tools to Unlock Biological Mechanisms in Type 1 Diabetes
Nick Holmes,
Anne Cooke
Abstract
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(170KB)
Pathogenic Mechanisms in Type 1 Diabetes: The Islet is Both Target and Driver of Disease
Kate L. Graham,
Robyn M. Sutherland,
Stuart I. Mannering,
Yuxing Zhao,
Jonathan Chee,
Balasubramanian Krishnamurthy,
Helen E. Thomas,
Andrew M. Lew,
Thomas W.H. Kay
Abstract
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(7.1 MB)
Comparative Genetics: Synergizing Human and NOD Mouse Studies for Identifying Genetic Causation of Type 1 Diabetes
John P. Driver,
Yi-Guang Chen,
Clayton E. Mathews
Abstract
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(345KB)
Protein Tyrosine Phosphatases and Type 1 Diabetes: Genetic and Functional Implications of PTPN2 and PTPN22
Karen Cerosaletti,
Jane H. Buckner
Abstract
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(763KB)
From Markers to Molecular Mechanisms: Type 1 Diabetes in the Post-GWAS Era
Alan G. Baxter,
Margaret A. Jordan
Abstract
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(1.0 MB)
Novel Biomarkers in Type 1 Diabetes
Yulan Jin,
Jin-Xiong She
Abstract
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(159KB)
Metabolomics in the Studies of Islet Autoimmunity and Type 1 Diabetes
Matej Oresic
Abstract
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(2.4 MB)
Chapter II. Prevention
Gut Microbiota and Type 1 Diabetes
Outi Vaarala
Abstract
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(132KB)
Virus Infections as Potential Targets of Preventive Treatments for Type 1 Diabetes
Noora Nurminen,
Sami Oikarinen,
Heikki Hyƶty
Abstract
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(416KB)
Helminth Infection and Type 1 Diabetes
Paola Zaccone,
Samuel W. Hall
Abstract
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(851KB)
Chapter III. Re-establishing Tolerance
Type 1 Diabetes Therapy Beyond T Cell Targeting: Monocytes, B Cells, and Innate Lymphocytes
F. Susan Wong,
Li Wen
Abstract
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(823KB)
Targeted Antigen Delivery to DEC-205+ Dendritic Cells for Tolerogenic Vaccination
Cathleen Petzold,
Sonja Schallenberg,
Joel N.H. Stern,
Karsten Kretschmer
Abstract
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(379KB)
Tolerance Strategies Employing Antigen-Coupled Apoptotic Cells and Carboxylated PLG Nanoparticles for the Treatment of Type 1 Diabetes
Suchitra Prasad,
Dan Xu,
Stephen D. Miller
Abstract
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(530KB)
Clinical Potential of Antigen-Specific Therapies in Type 1 Diabetes
Ken T. Coppieters,
Birgit Sehested Hansen,
Matthias G. von Herrath
Abstract
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(560KB)
Interleukin-1 Antagonists and Other Cytokine Blockade Strategies for Type 1 Diabetes
Thomas Mandrup-Poulsen
Abstract
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(204KB)
In Vivo Delivery of Nucleic Acid-Formulated Microparticles as a Potential Tolerogenic Vaccine for Type 1 Diabetes
Valentina Di Caro,
Nick Giannoukakis,
Massimo Trucco
Abstract
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(5.1 MB)
Chapter IV. Clinical Trials
Immune-Directed Therapy for Type 1 Diabetes at the Clinical Level: The Immune Tolerance Network (ITN) Experience
Mario R. Ehlers,
Gerald T. Nepom
Abstract
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(369KB)
CD3 Monoclonal Antibodies: A First Step Towards Operational Immune Tolerance in the Clinic
Lucienne Chatenoud,
Herman Waldmann
Abstract
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(143KB)
Chapter V. Beta-Cell Replacement
Islet Transplantation in Type 1 Diabetes: Ongoing Challenges, Refined Procedures, and Long-Term Outcome
A.M. James Shapiro
Abstract
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(327KB)
Islet Neogenesis: A Possible Pathway for Beta-Cell Replenishment
Susan Bonner-Weir,
Lili Guo,
Wan-Chun Li,
Limor Ouziel-Yahalom,
Philippe A. Lysy,
Gordon C. Weir,
Arun Sharma
Abstract
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(178KB)
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