Diabetic Perspectives
| Rev Diabet Stud,
2005,
2(4):228-234 |
DOI 10.1900/RDS.2005.2.228 |
The Application of Umbilical Cord Blood Cells in the Treatment of Diabetes Mellitus
Tomas Koblas1, S. Mitchell Harman2, Frantisek Saudek1
1Laboratory of Pancreatic Islets, Institute for Clinical and Experimental Medicine, Center for Cell Therapy and Tissue Repair, Prague, Czech Republic.
2Kronos Longevity Research Institute, Phoenix, AZ, USA.
Address correspondence to: Frantisek Saudek, e-mail: frantisek.saudek@medicon.cz.
Keywords: diabetes, umbilical cord blood, differentiation, β-cells
Abstract
In recent years, human umbilical cord blood (HUCB) has emerged as an attractive tool for cell-based therapy. Although at present the clinical application of HUCB is limited to the fields of hematology and oncology, a rising number of studies show potential for further application in the treatment of non-hematopoietic diseases. HUCB, with its real abundance, simple collection procedure and no serious ethical dilemmas, represents a valuable alternative to the use of other stem cell sources. The aim of this article is to review the literature on HUCB and to assess its eventual usability in the treatment of diabetes mellitus. This review presents some recent reports concerning pancreatic endocrine stem cells and their identification, HUCB stem cells and their advantages and, finally, the potential for converting HUCB-derived stem cells into insulin-producing β-cells.
Fulltext:
 HTML
,  PDF
(300KB)
This article has been cited by other articles:
|
Effect of human umbilical cord blood CD34+ progenitor cells transplantation in diabetic mice
AbdElabry Hasein M, Attia FM, Awad MM, Abdelaal HA, Elbarabary M
Int J Diabetes Dev Ctries 2011. 31(2):113-117h
|
|
|
Effect of transplantation of mesenchymal stem cells induced into early hepatic cells in streptozotocin-induced diabetic mice
Dinarvand P, Hashemi SM, Soleimani M
Biol Pharm Bull 2010. 33(7):1212-1217
|
|
|
Human umbilical cord blood as an emerging stem cell therapy for diabetes mellitus
Reddi AS, Kuppasani K, Ende N
Curr Stem Cell Res Ther 2010. 5(4):356-361
|
|
|
Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: preliminary report of 7 cases
Bahk JY, Jung JH, Han H, Min SK, Lee YS
Exp Clin Transplant 2010. 8(2):150-160
|
|
|
Islet neogenesis from the constitutively nestin expressing human umbilical cord matrix derived mesenchymal stem cells
Kadam SS, Bhonde RR
Islets 2010. 2(2):112-120
|
|
|
In vitro culture of keratinocytes from human umbilical cord blood mesenchymal stem cells: the Saigonese culture
Toai TC, Thao HD, Gargiulo C, Thao NP, Thuy TT, Tuan HM, Tung NT, Filgueira L, Strong DM
Cell Tissue Bank 2010. 11(3):269-280
|
|
|
Cell therapy for type-1 diabetes
Sokolova IB
Cell Tissue Biol 2009. 3(6):511-518
|
|
|
Insulin-producing cells derived from stem/progenitor cells: therapeutic implications for diabetes mellitus
Hori Y
Med Mol Morphol 2009. 42(4):195-200
|
|
|
In vitro culture and differentiation of osteoblasts from human umbilical cord blood
Toai TC, Thao HD, Thao NP, Gargiulo C, Ngoc PK, Van PH, Strong DM
Cell Tissue Bank 2009. Jun 30, epub ahead of print
|
|
|
Potential myogenic stem cell populations: sources, plasticity and application for cardiac repair
Schabort EJ, Myburgh KH, Wiehe JM, Torzewski J, Niesler CU
Stem Cells Dev 2009. 18(6):813-830
|
|
|
The current status of islet transplantation and its perspectives
Kobayashi N
Rev Diabet Stud 2008. 5(3):136-143
|
|
|
Stem cells and the mammary microenvironment
Booth BW, Boulanger CA, Smith GH
Breast Dis 2008. 29:57-67
|
|
|
Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer
Mimeault M, Batra SK
Gut 2008. 57(10):1456-1468
|
|
|
Mesenchymal Stem Cells - Sources and Clinical Applications
Klingemann H, Matzilevich D, Marchand J
Transfus Med Hemother 2008. 35(4):2
|
|
|
Stem Cell Strategies for Pancreatic beta-cell
Wu X, Woo M
Endocrinol Rounds 2008. 8(4):1-6
|
|
|
Characterization of adipose tissue-derived cells isolated with the Celution system
Lin K, Matsubara Y, Masuda Y, Togashi K, Ohno T, Tamura T, Toyoshima Y, Sugimachi K, Toyoda M, Marc H, Douglas A
Cytotherapy 2008. 10(4):417-426
|
|
|
Mesenchymal stem cells: Biology and clinical potential in Type 1 Diabetes Therapy
Liu M, Han ZC
J Cell Mol Med 2008. 12(4):1155-1168
|
|
|
Cellular therapies for type 1 diabetes
Lee DD, Grossman E, Chong AS
Horm Metab Res 2008. 40(2):147-154
|
|
|
Stem Cell Treatment for Complicated Diabetes
Bahk JY, Han H, Lee YS
Int J Stem Cells 2008. 1(1):91-95
|
|
|
Mesenchymal Stromal Cells from Umbilical Cord Blood
Bieback K, Kluter H
Curr Stem Cell Res Ther 2007. 2(4):310-323
|
|
|
Transplantation in the treatment of diabetes
Saudek F
Vnitr Lek 2007. 53(7-8):859-864
|
|
|
