Th17 Cells in Inflammatory Conditions

SciScript - Scientific article factory.
Professional proofreading by scientists and linguists.
Read more... klick here

http://www.sciscript.info/content/

Short Review

Rev Diabet Stud, 2006, 3(2):72-75

DOI 10.1900/RDS.2006.3.72

Th17 Cells in Inflammatory Conditions

Anne Cooke

Department of Pathology, University of Cambridge, Tennis Court Rd., Cambridge CB21QP, United Kingdom, e-mail: ac@mole.bio.cam.ac.uk.

Keywords: inflammatory disease, Th cell, regulatory T cell, Th17 cell, IL-17, IL-23, type 1 diabetes

Abstract

CD4⁺ T cells have been subdivided into different subsets, largely on the basis of the cytokines they produce. These subsets include Th1, Th2 and regulatory T cells. Recently, another population of T cells have been described, namely Th17, which are characterized by their production of IL-17. Two other important cytokines, which are related to each other, are associated with the development of Th cells, namely IL-12 and IL-23. While IL-12 plays a key role in the differentiation of naïve T cells to Th1 cells, IL-23 promotes the expansion of Th17 cells. IL-12 and IL-23 are heterodimers with a shared subunit, p40. They furthermore bind to receptors which have unique and shared subunits. Several previous studies have evaluated the role of IL-12 in inflammatory diseases on the basis of p40. Therefore a reevaluation of the role of IL-12 and Th1 cells in a range of inflammatory conditions has been carried out. This new wave of studies has resulted in the recognition of the role of IL-23 and Th17 cells in inflammatory conditions, such as arthritis and inflammatory bowel disease. There is also the speculation about a possible role in type 1 diabetes.

Fulltext: HTML , PDF (398KB)

This article has been cited by other articles:

	Gut microbiota and type 1 diabetes Vaarala O Rev Diabet Stud 2012. 9(4):251-259

	Pathogenic Mechanisms in Type 1 Diabetes: The Islet is Both Target and Driver of Disease Graham KL, Sutherland RM, Mannering SI, Zhao Y, Chee J, Krishnamurthy B, Thomas HE, Lew AM, Kay TW Rev Diabet Stud 2012. 9(4):148-168

	A phase 2, 24-week, randomized, placebo-controlled, double-blind study examining the efficacy and safety of an anti-interleukin-12 and -23 monoclonal antibody in patients with relapsing-remitting or secondary progressive multiple sclerosis Vollmer TL, Wynn DR, Alam MS, Valdes J Mult Scler 2011. 17(2):181-191

	Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis Mikulkova Z, Praksova P, Stourac P, Bednarik J, Michalek J J Neurol Sci 2011. 300(1-2):135-141

	Immunopathology of the human pancreas in type-I diabetes Richardson SJ, Willcox A, Bone AJ, Morgan NG, Foulis AK Semin Immunopathol 2011. 33(1):9-21

	Heat-killed Trypanosoma cruzi induces acute cardiac damage and polyantigenic autoimmunity Bonney KM, Taylor JM, Daniels MD, Epting CL, Engman DM PLoS One 2011. 6(1):e14571

	Th17 cells: positive or negative role in tumor? Ji Y, Zhang W Cancer Immunol Immunother 2010. 59(7):979-987

	Type 1 diabetes in BioBreeding rats is critically linked to an imbalance between Th17 and regulatory T cells and an altered TCR repertoire van den Brandt J, Fischer HJ, Walter L, Hünig T, Klöting I, Reichardt HM J Immunol 2010. 185(4):2285-2294

	Unregulated IL-23/IL-17 immune response in autoimmune diseases Costa VS, Mattana TC, da Silva ME Diabetes Res Clin Pract 2010. 88(3):222-226

	Numerical defects in CD8(+)CD28(-) T-suppressor lymphocyte population in patients with type 1 diabetes mellitus and multiple sclerosis Mikulkova Z, Praksova P, Stourac P, Bednarik J, Strajtova L, Pacasova R, Belobradkova J, Dite P, Michalek J Cell Immunol 2010. 262(2):75-79

	Functional alterations of proinflammatory monocytes by T regulatory cells: implications for the prevention and reversal of type 1 diabetes Sia C, Hänninen A Rev Diabet Stud 2010. 7(1):6-14

	Nephropathic complication of type-2 diabetes is following pattern of autoimmune diseases? Arababadi MK, Nosratabadi R, Hassanshahi G, Yaghini N, Pooladvand V, Shamsizadeh A, Hakimi H, Derakhshan R Diabetes Res Clin Pract 2010. 87(1):33-37

	Flt3-ligand decreases Th17 cells and SOCS proteins in the lung of house dust mite-sensitized and challenged mice McGee HS, Stallworth AL, Agrawal T, Shao Z, Lorence L, Agrawal DK Am J Respir Cell Mol Biol 2009. Nov 20, epub ahead of print

	Chronic inflammation as a manifestation of defects in immunoregulatory networks: implications for novel therapies based on microbial products Bottasso O, Docena G, Stanford JL, Grange JM Inflammopharmacology 2009. 17(4):193-203

	Serum antibodies and cytokines in C4-deficient mice and their responses to exercise Visetnoi S, Chawengkirttikul R, Chaiyaroj SC, Kitiyanant Y, Pholpramool C Asian Pac J Allergy Immunol 2009. 27(4):199-206

	Microarray analysis reveals difference in gene expression profiles of hair and wool sheep infected with Haemonchus contortus Mackinnon KM, Burton JL, Zajac AM, Notter DR Vet Immunol Immunopathol 2009. 130(3-4):210-220

	Cytokines in the beginning stages of the immune response Adler G Reumatologia 2009. 47(4):230-235

	An orally bioavailable synthetic analogue of an active DHEA metabolite reduces established disease in rodent models of rheumatoid arthritis Offner H, Firestein GS, Boyle DL, Pieters R, Frincke JM, Garsd A, White SK, Reading CL, Auci DL J Pharmacol Exp Ther 2009. 329(3):1100-1109

	TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin Castellanos-Rubio A, Santin I, Irastorza I, Castaño L, Carlos Vitoria J, Ramon Bilbao J Autoimmunity 2009. 42(1):69-73

	Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice Sgouroudis E, Albanese A, Piccirillo CA J Immunol 2008. 181(9):6283-6292

	Immunopathology of type 1 diabetes mellitus Gallardo CD, Guzman MA Arch Alergia Immunol Clin 2008. 39(4):151-160

	Down-Regulation of Allergic Responses in Conditions of Experimental Diabetes: A Role for Glucocorticoids? E Silva PM, Carvalho VF, Cordeiro RS, Martins MA Neuroimmunomodulation 2008. Epub ahead of print.

	Th17 cells in human disease Tesmer LA, Lundy SK, Sarkar S, Fox DA Immunol Rev 2008. 223:87-113

	Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis Ivory K, Chambers SJ, Pin C, Prieto E, Arques JL, Nicoletti C Clin Exp Allergy 2008. 38(8):1282-1289

	Novel immune regulatory pathways and their role in immune reconstitution syndrome in organ transplant recipients with invasive mycoses Singh N Eur J Clin Microbiol Infect Dis 2008. 27(6):403-408

	In Vitro Differentiation of Dendritic Cells in the Presence of Prostaglandin E2 Alters the IL-12/IL-23 Balance and Promotes Differentiation of Th17 Cells Khayrullina T, Yen JH, Jing H, Ganea D J Immunol 2008. 181(1):721-735

	Commentary on recent genetic studies Rhodes D Partn Seek Cure Newsl 2007. 3(1):12-15

Internal Link

Th17 Cells in Inflammatory Conditions (398KB)