Original Data

Gender-Specific Differences in the Association of Adiponectin Gene Polymorphisms with Body Mass Index

Ozra Tabatabaei-Malazy¹, Shirin Hasani-Ranjbar¹, Mahsa M. Amoli¹, Ramin Heshmat¹, Mohammadali Sajadi², Reza Derakhshan², Parvin Amiri¹, Mahsa Namakchian¹, Ebrahim Rezazadeh², Javad Tavakkoly-Bazzaz^1,3, Abbasali Keshtkar^1,4, Bagher Larijani¹

Manuscript submitted April 22, 2010; resubmitted May 29, 2010; accepted June 7, 2010.

Keywords: type 2 diabetes, adiponectin, polymorphism, body mass index, BMI, blood pressure, waist, gender, metabolic syndrome, polymerase chain reaction

Abstract

OBJECTIVE: Adiponectin gene polymorphisms are associated with obesity, metabolic syndrome and type 2 diabetes (T2D). The study evaluated possible associations of +45T/G and -11391G/A adiponectin gene polymorphisms with body mass index (BMI), waist circumferences (WC), and blood pressure in diabetic and non-diabetic Iranians. METHODS: This cross-sectional study involved two groups of subjects: 243 diabetic patients and 173 non-diabetic subjects recruited from Rafsanjan city in the south-east of Iran. RESULTS: No significant association was found between +45T/G and -11391G/A adiponectin gene polymorphisms and systolic or diastolic blood pressure. However, male carriers of the TT genotype of +45T/G had a significantly higher mean BMI than male GG homozygotes (p = 0.018). Also, male carriers of the GG genotype of -11391G/A had significantly higher mean BMI than male GA or AA homozygotes (p = 0.041). Female carriers of the GG genotype of -11391G/A had significantly higher mean WC than female GA or AA homozygotes (p = 0.038). CONCLUSIONS: We observed a significantly higher BMI in women, and GA or AA carriers of -11391G/A polymorphism. Also, there was a significantly lower WC in females and GG carriers of +45T/G. These results point to a gender-specific impact of the studied genotypes on BMI and WC.

Fulltext: HTML , PDF (114KB)

This article has been cited by other articles:

	Effect of the ADIPOQ Gene -11391G/A Polymorphism Is Modulated by Lifestyle Factors in Mexican Subjects Garcia-Garcia MR, Morales-Lanuza MA, Campos-Perez WY, Ruiz-Madrigal B, Maldonado-Gonzalez M, Vizmanos B, Hernandez-Canaveral I, Yanez-Sanchez I, Roman S, Panduro A, Martinez-Lopez E J Nutrigenet Nutrigenomics 2015. 7(4-6):210-222
	Adiponectin Gene Variants and Abdominal Obesity in an Iranian Population Payab M, Amoli MM, Qorbani M, Hasani-Ranjbar S Int J Endocrinol 2015. In press
	Association of adiponectin protein and ADIPOQ gene variants with lumbar disc degeneration Khabour OF, Abu-Rumeh L, Al-Jarrah M, Jamous M, Alhashimi F Exp Ther Med 2014. 8(4):1340-1344
	Association between ADIPOQ +45T>G polymorphism and type 2 diabetes: a systematic review and meta-analysis Fan Y, Wang K, Xu S, Chen G, Di H, Cao M, Liu C Int J Mol Sci 2014. 16(1):704-723
	Prevalence of obesity and overweight in adults and children in Iran; a systematic review Jafari-Adli S, Jouyandeh Z, Qorbani M, Soroush A, Larijani B, Hasani-Ranjbar S J Diabetes Metab Disord 2014. 13(1):121
	Involvement of adiponectin in early stage of colorectal carcinogenesis Tae CH, Kim SE, Jung SA, Joo YH, Shim KN, Jung HK, Kim TH, Cho MS, Kim KH, Kim JS BMC Cancer 2014. 14:811
	AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study Chu H, Wang M, Zhong D, Shi D, Ma L, Tong N, Zhang Z Diabetes Metab Res Rev 2013. 29(7):532-545
	Association of adiponectin with hypertension in type 2 diabetic patients: the gender effect Khabour OF, Wehaibi SH, Al-Azzam SI, Alzoubi KH, El-Akawi ZJ Clin Exp Hypertens 2013. 35(5):361-366
	Association of adiponectin (AdipoQ) and sulphonylurea receptor (ABCC8) gene polymorphisms with Type 2 Diabetes in North Indian population of Punjab Matharoo K, Arora P, Bhanwer AJ Gene 2013. 527(1):228-234
	The 3'-UTR of the adiponectin Q gene harbours susceptibility loci for atherosclerosis and its metabolic risk traits Muiya N, Al-Najai M, Tahir AI, Elhawari S, Gueco D, Andres E, Mazhar N, Altassan N, Meyer BF, Alshahid M, Dzimiri N BMC Med Genet 2013. 14:127
	Waist Circumference, Weight, and Body Mass Index of Iranians based on National Non-Communicable Disease Risk Factors Surveillance Ahranjani SA, Kashani H, Forouzanfar M, Meybodi HA, Larijani B, Aalaa M, Mohajeri-Tehrani M Iran J Public Health 2012. 41(4):35-45
	Genetic association of adiponectin gene polymorphisms (+45T/G and +10211T/G) with type 2 diabetes in North Indians Saxena M, Srivastava N, Banerjee M Diabetes Metab Syndr 2012. 6(2):65-69
	Apolipoprotein E gene polymorphism and its effect on anthropometric measures in normoglycemic subjects and type 2 diabetes Tabatabaei-Malazy O, Fakhrzadeh H, Qorbani M, Amiri P, Larijani B, Tavakkoly-Bazzaz J, Amoli MM J Diabetes Metab Disord 2012. 11(1):18
	Effect of adiponectin gene polymorphisms on waist circumference in patients with diabetes Hasani-Ranjbar S, Amoli MM, Tabatabaei-Malazy O, Rumi Y, Tavakkoly-Bazzaz J, Samimi H, Abbasifarid E J Diabetes Metab Disord 2012. 11(1):14
	Association of adiponectin and metabolic syndrome in women Sanjari M, Khodashahi M, Gholamhoseinian A, Shokoohi M J Res Med Sci 2011. 16(12):1532-1540