Original Data
Rev Diabet Stud,
2006,
3(1):21-30 |
DOI 10.1900/RDS.2006.3.21 |
ENPP1 K121Q Polymorphism is not Related to Type 2 Diabetes Mellitus, Features of Metabolic Syndrome, and Diabetic Cardiovascular Complications in a Chinese Population
Miao-Pei Chen1, Fu-Mei Chung1, Dao-Ming Chang1, Jack C-R Tsai1, Han-Fen Huang1, Shyi-Jang Shin2, Yau-Jiunn Lee1
1Department of Clinical Research, Pingtung Christian Hospital, Pingtung, 90000 Taiwan.
2Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, 80307 Taiwan.
Address correspondence to: Yau-Jiunn Lee, e-mail: t3275@ms25.hinet.net
Keywords: ENPP1, T2DM, metabolic syndrome, coronary artery disease, cerebrovascular disease
Abstract
BACKGROUND: Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) is known to influence insulin sensitivity by inhibiting insulin receptor signaling. A DNA polymorphism in the ENPP1 gene at exon 4 (K121Q) was demonstrated to be associated with insulin resistance, type 2 diabetes mellitus (T2DM), and a risk of early myocardial infarction, albeit with controversy. Our aim was to investigate any association of ENPP1 K121Q alleles with T2DM, features of the metabolic syndrome, and diabetic cardiovascular complications in a Chinese population of Han origin. METHODS: The ENPP1 K121Q polymorphism was determined by a restriction fragment-length polymorphism-polymerase chain reaction in 1,862 patients with T2DM and 844 non-diabetic subjects. RESULTS: The genotype distributions or Q-allele frequency were not statistically different between the diabetic and non-diabetic groups. The anthropometric parameters, systolic and diastolic blood pressures, lipid profiles, and serum creatinine levels of subjects with different ENPP1 K121Q polymorphisms were not statistically different in the two groups or even in the pooled data. When sub-group analyses of diabetic subjects were stratified according to BMI levels (greater or less than 27), gender, age of diabetes onset (older or younger than 60 years), and the presence or absence of a diabetic family history; this polymorphism was still not associated with T2DM. Nor was the ENPP1 K121Q polymorphism associated with the prevalence of coronary artery disease and ischemic cerebrovascular disease in patients with T2DM. CONCLUSION: The ENPP1 K121Q polymorphism is not related to T2DM, features of the metabolic syndrome, or diabetic macrovascular complications in a Chinese population.
Fulltext:
HTML
, PDF
(260KB)
This article has been cited by other articles:
|
The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese
Shi X, Wang L, Jin F, Sun J, Sun L, Tang L, Yang Z
Acta Diabetol 2011. In press
|
|
|
Genetic etiology of type 2 diabetes mellitus: a review
Kommoju UJ, Reddy BM
Int J Diabetes Dev Ctries 2011. 31(2):51-64
|
|
|
The ENPP1 K121Q polymorphism is not associated with type 2 diabetes and related metabolic traits in an Iranian population
Saberi H, Mohammadtaghvaei N, Gulkho S, Bakhtiyari S, Mohammadi M, Hanachi P, Gerayesh-Nejad S, Zargari M, Ataei F, Parvaneh L, Larijani B, Meshkani R
Mol Cell Biochem 2011. 350(1-2):113-118
|
|
|
The ENPP1 K121Q polymorphism is not associated with type 2 diabetes or obesity in the Chinese Han population
Zhao T, Liu Z, Zhang D, Liu Y, Yang Y, Zhou D, Chen Z, Yu L, Zhang Z, Feng G, He L, Xu H
J Hum Genet 2011. 56(1):12-16
|
|
|
ENPP1 K121Q genotype not associated with coronary artery calcification in Korean patients with type 2 diabetes mellitus
Jeong DJ, Lee DG, Kim HJ, Cho EH, Kim SW
Korean Diabetes J 2010. 34(5):320-326
|
|
|
The genetics of vascular complications in diabetes mellitus
Farbstein D, Levy AP
Cardiol Clin 2010. 28(3):477-496
|
|
|
Impact of ENPP1 and MMP3 gene polymorphisms on aortic calcification in patients with type 2 diabetes in a Korean population
Lee JE, Choi YK, Seo HA, Jeon JH, Jeong JY, Moon SS, Kim JG, Kim BW, Kim SW, Min Y, Kim JY, Lee IK
Diabetes Res Clin Pract 2010. 88(1):87-96
|
|
|
No association of TCF7L2 and ENPP1 gene polymorphisms in Malaysian type 2 diabetes mellitus with or without hypertension
Vasudevan R, Patimah I, Aisyah A, Mansor MS
Res J Biol Sci 2009. 4(6):703-709
|
|
|
Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population
El Achhab Y, Meyre D, Bouatia-Naji N, Berraho M, Deweirder M, Vatin V, Delplanque J, Serhier Z, Lyoussi B, Nejjari C, Froguel P, Chikri M
Diabetes Metab 2009. 35(1):37-42
|
|
|
Further Evidence For the Role of ENPP1 in Obesity: Association With Morbid Obesity in Finns
Valli-Jaakola K, Suviolahti E, Schalin-Jäntti C, Ripatti S, Silander K, Oksanen L, Salomaa V, Peltonen L, Kontula K
Obesity (Silver Spring) 2008. 16(9):2113-2119
|
|
|
Effect of ENPP1/PC-1-K121Q and PPARgamma-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population
Bouhaha R, Meyre D, Kamoun HA, Ennafaa H, Vaillant E, Sassi R, Baroudi T, Vatin V, Froguel P, Elgaaied A, Vaxillaire M
Diabetes Res Clin Pract 2008. 81(3):278-283
|
|
|
Polygenic contribution to obesity: genome-wide strategies reveal new targets
Körner A, Kiess W, Stumvoll M, Kovacs P
Front Horm Res 2008. 36:12-36
|
|
|
Polymorphisms of the ENPP1 gene are not associated with type 2 diabetes or obesity in the Chinese Han population
Zhao T, Zhang D, Liu Y, Zhou D, Chen Z, Li S, Yu L, Liu S, Zhang Z, Feng G, He L, Xu H
Nature Proceedings 2008.
|
|
|